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Hindi Journal of Regenerative MedicineISSN: 2325-9620
Andrew K Wise Author
Subjects of specialization
Affiliation
Neurophysiology
Institute of Bionics, Melbourne, Australia
Biography
Dr Wise graduated from Monash University (PhD) in 2002 where he studied neurophysiology of the sensorimotor system. He was a post doctoral research Fellow at the Bionic Ear Institute (2001-2003). He moved to Bristol UK where he took up post doctoral position (2003-2006) before returning to Melbourne in 2006 to continue research at the Bionics Institute.
Publications
Research Article Subscription
Regeneration of Cochlear Hair Cells with Atoh1 Gene Therapy after Noise-Induced Hearing Loss
Author(s): Andrew K Wise, Brianna O Flynn, Patrick J Atkinson, James B Fallon, Madeline Nicholson and Rachael T Richardson
Background: Degeneration of hair cells in the mammalian cochlea results in irreversible hearing loss with no current treatment options to regain lost hair cell function. The Atoh1 gene is necessary for hair cell development and recent research has shown that Atoh1 gene therapy promotes new hair cell formation and hearing restoration in adult rodent deafness models.
Objective: The aim of this study was to examine new hair cell formation via Atoh1 gene therapy in noise-deafened adult guinea pigs. Methods: Guinea pigs were deafened by noise exposure (130 dB, 11-13 kHz, 2 hours). After two weeks, the left cochleae were injected wit... view more»
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