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Hindi Journal of Chemistry and Applied Chemical EngineeringISSN : 2576-3954
Antonio Feula Author
Subjects of specialization
Affiliation
Chemistry, Thermo Dynamics, Thermal decomposition, Mechanistic aspects, Combustion
Antonio Feula; Bristol Myers Squibb.
Biography
Antonio Feula; Bristol Myers Squibb. He stated that, "The stereochemical divergent synthesis of cis and trans substituted pyrrolidines supports an ion part, aziridinium, isomerisation pathway for azetidine to pyrrolidine isomerisation."
Publications
Short Communication Open Access
Synthesis of azetidines and pyrrolidines towards medicinal chemistry and organocatalysis applications
Author(s): Antonio Feula
Room temperature iodocyclisation of homoallylamines stereoselectively delivers functionalised 2- (iodomethyl)azetidine derivatives in high yield. Increasing reaction temperature from 20 °C to 50 °C switches the reaction outcome to realise the stereoselective formation of functionalised 3-iodopyrrolidine derivatives. It was shown that these pyrrolidines are formed via thermal isomerisation of the aforementioned azetidines. Primary and secondary amines could be reacted with iodomethyl azetidine derivatives to deliver stable methylamino azetidine derivatives. With subtle changes to the reaction sequences homoallyl amines could be stereoselectively converted to either cis- or trans- substituted 3-amino pyrrolidine derivatives at will. The stereochemical divergent synthesis of cis an... view more»
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