Arcot Dheenadayalu Nageswari Author

Short Communication Open Access

Effect of Rifampin with bio-enhancer in the treatment of newly diagnosed sputum positive pulmonary tuberculosis patients: A double center study- Arcot Dheenadayalu Nageswari- Tagore Medical College and Hospital

Author(s):

Arcot Dheenadayalu Nageswari 

Aim: Tuberculosis was declared as global emergency by WHO in 1993. DOTS therapy recommended by WHO is highly effective in an active drug susceptible TB as long as patient completes the course. Adverse effect of anti TB drugs is one of the most common reason for non-adherence eventually contributing to treatment failure, relapse or emergence of drug resistance. The standard treatment for newly diagnosed tuberculosis patients consists of an intensive phase for two months with four drugs (HRZE), followed by continuation phase for four months with two drugs (HR). Rifampicin, which is very effective against mycobacterium tuberculosis, in both phase of treatment has certain concerns, which included decreased bioavailability with chronic use and hepatotoxicity. To overcome these concerns a new... view more»

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