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Hindi Journal of Chemistry and Applied Chemical EngineeringISSN : 2576-3954
B Moon Kim Author
Subjects of specialization
Affiliation
Chemistry, Thermo Dynamics, Thermal decomposition, Mechanistic aspects, Combustion
Massachusetts Institute of Technology, Merck and Co Inc West Point, Seoul National University.
Biography
B Moon Kim; Massachusetts Institute of Technology, Merck and Co Inc West Point, Seoul National University. He stated that, "Combinations of direct acting antivirals (DAA) including HCV NS3/4A protease inhibitors such as boceprevir, telaprevir, paritaprevir, and grazoprevir, polymerase inhibitors such as sofosbuvir and dasabuvir, and NS5A inhibitors such as daclatasvir, ledipasvir, ombitasvir, elbasvir and velpatasvir have shown successful arrest of the infection."
Publications
Short Communication Open Access
Extremely potent, pan-genotypic Hepatitis C virus NS5A inhibitors based on novel core structures
Author(s): B Moon Kim
Hepatitis C virus (HCV) infection often leads to serious liver diseases such as cirrhosis followed eventually by hepatocellular carcinoma. Several HCV RNA gene products (NS2, NS3, NS4A, NS4B, NS5A and NS5B) involved in the reproduction of HCV have been instensively studied for new therapeutic target identification. Recently, combinations of direct acting antivirals (DAA) including HCV NS3/4A protease inhibitors such as boceprevir, telaprevir, paritaprevir, and grazoprevir, polymerase inhibitors such as sofosbuvir and dasabuvir, and NS5A inhibitors such as daclatasvir, ledipasvir, ombitasvir, elbasvir and velpatasvir have shown successful arrest of the infection. However, even with the new DAA’s, resistance to the drugs in patients infected with various strains of HCV has emerged. ... view more»
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