HIV and AIDS Research Journal

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Crouzat F Author

Subjects of specialization
Medicine, NNRTI resistance

Affiliation
Maple Leaf Medical Clinic, Canada Department of Medicine, University of Toronto, Canada Women

Biography

Crouzat F is currently principal investigator for clinical trials investigating new antiretroviral medications and is involved in several other research trials and educational programs led by colleagues. Fred also leads the endeavour aimed at providing MLMC with an electronic medical record database system.


Publications

Research Article Open Access

Impact of Baseline NNRTI Resistance in Antiretroviral-naïve Patients with HIV in A Large Urban Clinic

Author(s):

Steinberg S, Loutfy M, Sandler I, Varriano B, Smith G, Kovacs C, Brunetta J, Chang B, Merkley B, Tilley D, Fletcher D, Acsai M, Knox D and Crouzat F

Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are prone to baseline resistance and potential early treatment failure. We investigated the NNRTI resistance profiles of antiretroviral therapy (ART)–naive patients with HIV in a large urban clinic and assessed their response to initial ART.

Materials and Methods: This was a retrospective cohort study of ART-naive patients, who had baseline genotypes, starting ART prior to July 16, 2015. Cox regression was used to determine the impact on time to viral suppression with baseline NNRTI resistance as the primary covariate of interest. Of those who achieved virologic suppression, Cox regression was used to determine the impact on viral rebound [viral load (VL) ≥ 200 copies/... view more»

Abstract HTML PDF



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