Dahal K Author

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Combined Lipid Lowering by Ezetimibe and Statin and Coronary Plaque Regression: A Meta- Analysis of Randomized Controlled Trials

Author(s):

Sharma SP, Dahal K, Kunwar S and Rijal J

Background: It is not clear whether the addition of ezetimibe to statin will result in greater reduction in coronary plaque. We aimed to perform a meta-analysis of all RCTs and prospective studies that evaluated role of dual lipid lowering strategy in atherosclerosis regression. Methods: We searched PubMed, EMBASE, Cochrane CENTRAL, Scopus and relevant references for RCTs (inception through December 20, 2015 without language restrictions) and performed meta-analysis using random effects model. Percentage change in plaque volume, change in lumen volume, percentage change in LDL, HDL and hsCRP were measured outcomes. Results: 3 RCTs and 1 prospective non randomized trial with a total population of 554 comprising mostly of Asian population were analyzed. Statin plus ezetimibe showed signif... view more»

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