Daniel Alejandro Lerman Author
Subjects of specialization
Affiliation
Aortic valve calcification disease, Aortic valve interstitial cells
Department of Cardiothoracic Surgery, Royal Infirmary Hospital of Edinburgh(NHS Lothian) The University of Edinburgh, United Kingdom
Department of Cardiothoracic Surgery, Royal Infirmary Hospital of Edinburgh(NHS Lothian) The University of Edinburgh, United Kingdom Denosumab is a fully human monoclonal antibody and novel antiresorptive agent that works by binding receptor activator of nuclear factor kappa-β ligand (RANKL) and inhibiting the signaling cascade that causes osteoclast maturation, activity, and survival.
Research Article Open Access
Author(s): Daniel Alejandro Lerman, Sai Prasad and Nasri Alotti
Denosumab could be a Potential Inhibitor of Valvular Interstitial Cells Calcification in vitro
Objective: Denosumab is a fully human monoclonal antibody and novel antiresorptive agent that works by binding receptor activator of nuclear factor kappa-β ligand (RANKL) and inhibiting the signaling cascade that causes osteoclast maturation, activity, and survival. We aimed to elucidate the effect of Denosumab in the process of spontaneous and induced calcification in an in vitro porcine valvular interstitial cells (VICs) model.
Materials and Methods: VICs were extracted from fresh porcine hea... view moreĀ»