International Journal of Cardiovascular ResearchISSN: 2324-8602

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Daniel Alejandro Lerman Author

s0978484@staffmail.ed.ac.uk 44-7854059667 | 44-785405966

Subjects of specialization
Aortic valve calcification disease, Aortic valve interstitial cells

Affiliation
Department of Cardiothoracic Surgery, Royal Infirmary Hospital of Edinburgh(NHS Lothian) The University of Edinburgh, United Kingdom

Biography

Department of Cardiothoracic Surgery, Royal Infirmary Hospital of Edinburgh(NHS Lothian) The University of Edinburgh, United Kingdom  Denosumab is a fully human monoclonal antibody and novel antiresorptive agent that works by binding receptor activator of nuclear factor kappa-β ligand (RANKL) and inhibiting the signaling cascade that causes osteoclast maturation, activity, and survival. 

Publications

Research Article Open Access

Using Na3PO4 to Enhance In vitro Animal Models of Aortic Valve Calcification

Author(s):

Daniel Alejandro Lerman, Sai Prasad and Nasri Alotti

Using Na3PO4 to Enhance In vitro Animal Models of Aortic Valve Calcification

Background/Objectives: The pathogenesis of calcific aortic valvular disease (CAVD) involves an active inflammatory process of valvular interstitial cells (VICs) characterized by the activation of specific osteogenic signaling pathways and apoptosis. This process can be studied by analyzing certain molecular markers and gene expression pathways of spontaneous calcification. The purpose of our study is to investigate the role of sodium phosphate (Na3PO4) as a calcification promoter, with the... view more»

DOI: 10.4172/2324-8602.1000250

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