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Hindi Journal of Blood Research & Hematologic Diseases
Deborah L White Author
Subjects of specialization
Affiliation
Wnt/?-Catenin; , Hematopoietic stem cell; Self-renewal; , Leukemic stem cell; , Myeloid leukemia; , Drug-Resistance
Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia
Biography
Prof Deborah White is the Director of Cancer Research and Deputy Cancer Theme Leader at the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide. Deborah White is a Principal Research Fellow with SAHMRI, and a Professor in both Medicine and Pediatrics at the University of Adelaide. In addition, she is a Fellow of the Faculty of Science (Royal College of Pathologists of Australia) a member of the American, European and Australian Societies of Haematology and the International Children’s Oncology Group.
Publications
Review Article Open Access
The Role of Wnt/β -Catenin Signaling in Normal and Malignant Hematopoiesis, Hemostasis
Author(s): Teresa Sadras, Richard J D’Andrea and Deborah L White
The Wnt/β-catenin signaling plays indispensable roles in embryonic development and adult homeostasis. Through diverse mechanisms which are partially defined, abnormal activation of β-catenin occurs frequently in neoplastic disease. A critical function for Wnt/β-catenin in solid tumors, in particular colorectal cancer, has been well characterized. Increasing evidence indicates that this pathway is also deregulated in hematological malignancies. In acute myeloid leukemia, enhanced β-catenin levels are observed in a large proportion of patients, and correlates with... view more»
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