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Hindi Journal of Blood Research & Hematologic Diseases
Dharmesh M Patel Author
Subjects of specialization
Affiliation
Acute myeloid leukemia, M-FISH, Conventional cytogenetic analysis
Cell Biology Division, The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad-380016, India
Biography
Dharmesh M Patel is the Director of Cancer Research and Deputy Cancer Theme Leader at the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide. Deborah White is a Principal Research Fellow with SAHMRI, and a Professor in both Medicine and Pediatrics at the University of Adelaide. In addition, she is a Fellow of the Faculty of Science (Royal College of Pathologists of Australia) a member of the American, European and Australian Societies of Haematology and the International Children’s Oncology Group.
Publications
Research Article Open Access
Characterization of Complex Chromosomal Rearrangements in Acute Myeloid Leukemia: FISH and Multicolor FISH Add Precision in Defining Abnormalities Associated with Poor Prognosis
Author(s): Pina J Trivedi, Dharmesh M Patel, Manisha M Brahmbhatt and Prabhudas S Patel
Introduction: The identification of specific chromosome abnormalities in Acute Myeloid Leukemia (AML) is the important for the stratification of patients into the appropriate treatment protocols. However, a significant proportion of diagnostic bone marrow karyotype in AML is reported as normal by conventional cytogenetic analysis. It is suspected that this karyotype may conceal the presence of diagnostically significant chromosome rearrangements. Complex chromosomal aberrations can be detected in a substantial proportion of AML, which are associated with very poor prognosis. Conventional cytogenetic analysis cannot accurately define the specific alterations in Complex chromosomal aberrations. M-FISH al... view more»
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