Elena V Orlova Author

Annual Meeting Abstract Open Access

Euro Virology 2017: Advances in methods used to study structure and function of viruses - Elena V Orlova - University of London

Author(s):

Elena V Orlova

Viruses are biomolecular nanomachines designed to infect cellular hosts with high efficiency and specificity. Therefore, they are intrinsically flexible and certainly exist in more than one conformation that can be visualized at almost native situations via present day structural strategies, along with Cryo-electron microscopy (EM). Advances of the remaining decade in generation and software improvement caused the revelation of structural variations in complexes and upgrades in a decision of EM systems. Structural evaluation based totally on single-particle methods indicates several processes for the separation of conformational states and thus disclosure of the functioning mechanisms of complexes. Revelation of the virus hobby thru structural evaluation calls for the exam of huge datas... view more»

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