Erlacirc;nia Alves de Siqueira Author

Editorial Open Access

The Cardiovascular Risk Research in Alzheimer’s Disease and Other Neurodegenerative Diseases

Author(s):

Tiago Lima Sampaio and Erlânia Alves de Siqueira

The occurrence of chronic and neurodegenerative diseases is epidemiologically important in elderly population, including Alzheimer’s Disease (AD). Risk factors such as diabetes, obesity, hypertension, Cardiovascular Diseases (CVD), hyperlipidemia, hyperhomocysteinemia, and smoking can lead to Cerebrovascular Diseases (CBVD). The neurodegeneration is consequence of cumulative macro and microcirculatory damage, corroborating to increase in systolic pressure, neuroinflammation, oxidative stress, and excitotoxicity. There are some intersections between AD and CVD. For example, ε4 allele of the Apolipoprotein E (APOE) gene is a risk; low plasma levels of ApoE protein favor the risk of AD, regardless of the APOE genotype. Furthermore, the insulin resistance causes atrophy of the... view more»

DOI: 10.37532/icrj.2021.10(1).430

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