Frazier OH Author

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Cardiomyocyte and Adrenoreceptor Modeling with Fluorescence Deconvolution Microscopy to Understand Heart Repair as a Result of Ventricular Unloading: Cell culture to LVAD

Author(s):

Poindexter BJ, Frazier OH and Bick RJ

Cardiomyocyte and Adrenoreceptor Modeling with Fluorescence Deconvolution Microscopy to Understand Heart Repair as a Result of Ventricular Unloading: Cell culture to LVAD

Objective: This research describes changes in number, density and localization of adrenoreceptors (ARs) following left ventricular unloading, after earlier reports of a loss of adrenoreceptors in heart failure, as well as cardiomyocyte dedifferentiation, another repair mechanism associated with heart failure, and suggests how these two ‘protective’ mechanisms work together to spare cardiac muscle from damage.

Hypothesis: view more»

DOI: 10.4172/2324-8602.1000234

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