George U Eleje Author

Special Issue Article Open Access

Prophylactic risk-reducing salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations: A systematic review and meta-analysis.

Author(s):

George U Eleje

Introduction & Objective: Prophylactic risk-reducing Salpingo-oophorectomy (RRSO) refers to surgical removal of both fallopian-tubes and ovaries in women not thought to have cancer prior to surgical procedure but have a high lifetime risk. Despite previous studies, the role of RRSO in reducing breast and High-grade Serous Cancer (HGSC) of ovarian, tubal and peritoneal origin are uncertain. This study assesses benefits and harms of prophylactic RRSO in women with BRCA1 or BRCA2 mutations.

Method: We searched Cochrane Central Register of Controlled Trials, MEDLINE /Embase Ovid and trial registries, and abstracts with no language restrictions up to July 2017. We included non-randomized trials that used statistical adjustment analyses comparing RRSO versus no RRSO in w... view more»

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