H. Bing Thio Author

Research Article Open Access

Aging immune system (immunosenescence) and the skin

Author(s):

H. Bing Thio

A well-established feature of physiological ageing in the
skin is an impaired epithelial barrier function. More
“danger” signals will then easily enter the skin and quickly
be noticed by the innate immune cells in the skin. The
functional integrity of the immune system during the
natural course of aging is an important issue. There is
an accumulating body of evidence that a decline in immune
function with age is common to most if not all vertebrates.
Almost all of the immune system components
undergo an aging-related alteration, thus impacting the
innate and adaptive immunity. The age-related decline in
the normal functions of immune system is referred to by
the specific term “immunosen... view more»

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