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Hindi Journal of Chemistry and Applied Chemical EngineeringISSN : 2576-3954
Hiromi Ii Author
Subjects of specialization
Affiliation
Chemistry, Thermo Dynamics, Thermal decomposition, Mechanistic aspects, Combustion
Hiromi Ii; Chemistry Department, College of Science- Taif University, KSA.
Biography
Hiromi Ii; Chemistry Department, College of Science- Taif University, KSA. He stated that, "However, no signal derived from NBD was observed inside cells. In order to improve its permeability, we generated a less polar prodrug “Nα-methoxyglutaryl-L-Lys(NBD)-OCH2OCOCH3 (Me-gKFA-AM)” where carboxylates in the structure of the parent inhibitor were substituted by alkyl esters."
Publications
Short Communication Open Access
A novel prodrug of gamma glutamylcyclotransferase inhibitor has anti-proliferative activity in-vitro and anti-cancer activity in-vivo
Author(s): Hiromi Ii
C7orf24 was discovered as a highly expressed protein in bladder cancers by a proteomic analysis and later identified as the ï§-glutamylcyclotransferase (GGCT). The silencing of GGCT using siRNA inhibited cancer cell proliferation and tumor growth in mice inoculated with cancer cells. However, the relationship between GGCT enzymatic activity and these phenotypes remained unknown. Therefore, we tried to identify a potent GGCT inhibitor and investigated its anti-cancer activity in vitro and in a xenograft mouse model. We performed a screening of GGCT inhibitors from 41 candidate compounds, and identified N-glutaryl-L-Ala (GA) that showed the highest inhibitory activity. Next, we used a NBD fluorochrome-tagged GA, Nα-glutaryl-L-Lys (NBD), to evaluate cell permeability. However, no... view more»
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