Hiroyuki Yamada | Author | SciTechnol | International Journal of

Hiroyuki Yamada Author

hiyamada@koto.kpu-m.ac.jp +81-75-251-5511 | +81-75-251-5

Subjects of specialization
Atherosclerosis, Renin angiotensin system

Affiliation
Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Biography

Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan Histochemical analysis of brachiocephalic artery at 19 weeks of age showed a marked reduction of necrotic core area in ARB-treated mice.

Publications

Research Article Open Access

Short-Term Treatment with an Angiotensin II Receptor Blocker Prevents Necrotic Core Formation by Inhibiting Oxidative Stress-Mediated Apoptosis in Macrophages

Author(s):

Sou Kishida, Hiroyuki Yamada, Noriyuki Wakana, Hiroyuki Kawahito, Daisuke Irie, Taku Kato, Masakazu Kikai, Kensuke Terada, Keita Yamamoto, Naotoshi Wada, Shinichiro Motoyama, Hiroki Takata, Hirokazu Yokoi, Yoshinori Tsubakimoto, Takehiro Ogata, Tomomi Ueyama and Satoaki Matoba

Short-Term Treatment with an Angiotensin II Receptor Blocker Prevents Necrotic Core Formation by Inhibiting Oxidative Stress-Mediated Apoptosis in Macrophages

Objective: To study the role of angiotensin II (Ang II) type 1 receptor (AT1R) on necrotic core formation associated with endoplasmic reticulum (ER) stress-induced macrophage apoptosis.

Methods and Results: Eight-week-old ApoE-deficient mice were fed a high-cholesterol diet and administered AT1R blocker (ARB), hydra... view more»

DOI: 10.4172/2324-8602.1000252

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