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Hindi Journal of Veterinary Science & Medical DiagnosisISSN: 2325-9590
Hong Gao Author
Subjects of specialization
Affiliation
Veterinary Pathobiology
College of Veterinary Science, Yunnan Agricultural University, Kunming, PR China
Biography
Mr. Hong Gao, belongs to the department of Veterinary Sciences, interest in the field of Ageing; Capillary electrophoresis; Physiological stages; Serum proteins; Sheep, from Yunnan Agricultural University, Kunming, PR China
Publications
Research Article Subscription
Cation A Protects against LPSInduced Liver Injury by Reducing Endogenous CO Production in Rats
Author(s): Peng Xiao, Guowen Fu, Yulin Yan, Libo Gao, Chaoying Liu, Chunlan Shan, Ru Zhao and Hong Gao*
Carbon monoxide (CO) is a naturally occurring gaseous transmitter that plays important roles in normal physiology and liver disease. Cation A (CA) has a protective effect on liver injury caused by lipopolysaccharide (LPS). To investigate the protective effects of CA on the LPS-induced liver injury using an endotoxemic rat model, male and female SD rats with acute endotoxemia and pretreated with CA were sacrificed. Liver CO production, liver heme oxygenase-1(HO-1) mRNA, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, and histopathological alterations in the liver at different time points after challenge were determined. After pretreatment with CA in the endotoxemic rats, the liver damage was alleviated, the generation of endogenous CO in plasma was reduced, a... view more»
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