International Journal of Mental Health & PsychiatryISSN: 2471-4372

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Jirui Hou Author

jiruih@gmail.com

Subjects of specialization
cAMP; Phosphodiestease; Serotonin; Zembrin extract; Sceletium tortuosum; Alzheimer?s disease

Affiliation
Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada

Biography

Jirui Hou belongs to Lawson Health Research Institute and his interests are Phosphodiestease; Serotonin; Zembrin extract; Sceletium tortuosum; Alzheimer’s disease and his one of the publication is Phase Behavior of Multicomponent Hydrocarbons in Organic Nanopores Under the Effects of Capillary Pressure and Adsorption Film

Publications

Review Article Subscription

Exploring Zembrin Extract Derived from South African Plant, Sceletium tortuosum in Targeting cAMP-driven Phosphodiesterase (PDE) Signaling in Alzheimer’s Disease: Synthesis of Evidence

Author(s):

Simon Chiu, Hana Raheb, Kristen Terpstra, JoshVaughan, Michel Farina-Woodbury, Yves Bureau, Zack Cernovsky, Jirui Hou, John Copen, Mariwan Husni, Vladimir Badmeav, Ana Hategan, Mujeeb Shad, Zach Suntras, Nigel Gericke

Recently with the changing landscape of the aging population and the increase in incidence of Alzheimer’s disease (AD), there has been marked interest to develop strategies to prevent, delay and modify AD. We review the diverse lines of evidence in support of the emerging role of cAMP-mediated Phosphodiesterase (PDE) signalling with respect to aging, inflammation and depression. In view of the link of PDE to Epigenetic complex, targeting PDE through designing modulators and inhibitors of PDE may represent a novel approach in AD therapeutics. We... view more»

DOI: 10.4172/2471-4372.1000104

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