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Hindi International Journal of Mental Health & PsychiatryISSN: 2471-4372
John Copen Author
Subjects of specialization
Affiliation
cAMP; Phosphodiestease; Serotonin; Zembrin extract; Sceletium tortuosum; Alzheimer?s disease
Department of Psychiatry, University British Columbia; University of Victoria Medical Campus, Victoria, BC Canada
Biography
John Copen belongs to Department of Psychiatry and his areas of interest are EMR Epigenetics Parkinson's Disease Healthcare Informatics Health Informatics Health Information Management Medical Informatics Telemedicine Information Technology Knowledge Management and his one of the publication is Translating Curry Extract to Novel Therapeutic Approach in Schizophrenia: the Emerging Role of Epigenetics Signaling
Publications
Review Article Subscription
Exploring Zembrin Extract Derived from South African Plant, Sceletium tortuosum in Targeting cAMP-driven Phosphodiesterase (PDE) Signaling in Alzheimer’s Disease: Synthesis of Evidence
Author(s): Simon Chiu, Hana Raheb, Kristen Terpstra, JoshVaughan, Michel Farina-Woodbury, Yves Bureau, Zack Cernovsky, Jirui Hou, John Copen, Mariwan Husni, Vladimir Badmeav, Ana Hategan, Mujeeb Shad, Zach Suntras, Nigel Gericke
Recently with the changing landscape of the aging population and the increase in incidence of Alzheimer’s disease (AD), there has been marked interest to develop strategies to prevent, delay and modify AD. We review the diverse lines of evidence in support of the emerging role of cAMP-mediated Phosphodiesterase (PDE) signalling with respect to aging, inflammation and depression. In view of the link of PDE to Epigenetic complex, targeting PDE through designing modulators and inhibitors of PDE may represent a novel approach in AD therapeutics. We... view more»
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