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Hindi International Journal of Cardiovascular ResearchISSN: 2324-8602
Josephine Buescher Author
Subjects of specialization
Affiliation
Cardiovascular disease, Endothelial progenitor cells, Circulating endothelial cells
Josephine Buescher, Department of Cardiology, Charit
Biography
Josephine Buescher, Department of Cardiology, Charité Universitätsmedizin, Campus Virchow-Klinikum, Berlin, Germany E-mail: josephine. wagner@charite.de. The endothelium has a pivotal role not just in establishing the functional integrity of the vasculature, but also in the regulation of blood pressure, coagulation, and leukocyte migration
Publications
Research Article Open Access
Test-Retest Reliability of Flow Cytometric Quantification of Circulating Endothelial Cells and Endothelial Progenitor Cells in Cardiovascular Diseases
Author(s): Josephine Buescher, , Fabian Weisrock , Max Fritschka, Sebastian Beckmann , Simon Litmeier , Elvis Tahirovic , Sara Radenovic , Andreas Busjahn , Thomas Krahn , Wilfried Dinh and Hans-Dirk Düengen
Circulating Endothelial Cells (CECs) and Endothelial Progenitor Cells (EPCs) are gaining importance as quantifiable surrogate biomarkers of Endothelial Dysfunction (ED). Lack of a common definition and consequently, a standardized quantification method has limited clinical applicability of these biomarkers. A reliable, reproducible, and practicable method is required to achieve the full potential of these parameters. The objective of this study was to evaluate the test-retest reliability over a short period of time (~7 days) of flow cytometric quantification of CECs and EPCs in human whole blood from patients with cardiovascular disease. 100 patients (mean age 65 years ± 10 years, 30 women) were enrolled into a prospective study consisting of 4 patients groups: Heart Failure with... view more»
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