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Hindi International Journal of Mental Health & PsychiatryISSN: 2471-4372
JoshVaughan Author
Subjects of specialization
Affiliation
cAMP; Phosphodiestease; Serotonin; Zembrin extract; Sceletium tortuosum; Alzheimer?s disease
Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada
Biography
Josh grew up in the San Francisco bay area and had an interest in science from an early age. He studied chemistry at Reed College in Portland, OR and earned a Ph.D. in physical chemistry at MIT where he worked in the lab of Keith Nelson on applications of adaptive optics to ultrafast spectroscopy. For his postdoctoral research in Xiaowei Zhuang's lab at Harvard he developed tools for super-resolution fluorescence microscopy and studied virus transport. His current interests include developing new tools to extract molecular detail from intact biological specimens..
Publications
Review Article Subscription
Exploring Zembrin Extract Derived from South African Plant, Sceletium tortuosum in Targeting cAMP-driven Phosphodiesterase (PDE) Signaling in Alzheimer’s Disease: Synthesis of Evidence
Author(s): Simon Chiu, Hana Raheb, Kristen Terpstra, JoshVaughan, Michel Farina-Woodbury, Yves Bureau, Zack Cernovsky, Jirui Hou, John Copen, Mariwan Husni, Vladimir Badmeav, Ana Hategan, Mujeeb Shad, Zach Suntras, Nigel Gericke
Recently with the changing landscape of the aging population and the increase in incidence of Alzheimer’s disease (AD), there has been marked interest to develop strategies to prevent, delay and modify AD. We review the diverse lines of evidence in support of the emerging role of cAMP-mediated Phosphodiesterase (PDE) signalling with respect to aging, inflammation and depression. In view of the link of PDE to Epigenetic complex, targeting PDE through designing modulators and inhibitors of PDE may represent a novel approach in AD therapeutics. We... view more»
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