KeWei Wang Author

Short Communication Open Access

Activation of temperature-sensitive Ca2+-permeable TRPV3 channels by natural -hydroxyl acids causes exfoliation for skin-resurfacing

Author(s):

KeWei Wang

Chemical peeling has been a conventional chemical exfoliation process or cosmetic treatment that improves the appearance of the skin. Chemical peels use different types of fruit acids to cause skin to exfoliate or eventually peel off to help diminish the look of wrinkles and aging. However, the molecular mechanism underlying the exfoliation effect induced by fruit acids remains largely unknown. In this talk I will present lines of evidence that activation of temperature-sensitive Ca2+-permeable transient receptor potential vanilloid 3 (TRPV3) channels by natural -hydroxyl acids causes exfoliation for skin-resurfacing. TRPV3 channel in keratinocytes is potently activated by intracellular acidification induced by glycolic acid. Intracellular acidification leads to direct ac... view more»

Abstract