KeWei Wang Author

Short Communication Open Access

Activation of thermoTRPV3 channels accounts for abnormal hair growth by natural skin sensitizer carvacrol

Author(s):

Yaxuan Qu, Kangjiao Yan, Xiaoying Sun, Gongxin Wang, Yani Liu and KeWei Wang

Hair growth starts from hair follicles that reside in dermis, and abnormal hair growth is an early sign of hair follicle disease or systemic illness such as alopecia or hair loss. Therefore, understanding the cause of dysfunctional hair follicles is critical to prevention of hair loss or alleviating dermatologic or systemic diseases with hair abnormalities. The outer root sheath (ORS) cells of human hair follicles are fundamental for maintaining the intact structure of hair follicles and regulating hair growth. We found that pharmacological activation of cutaneous warm-temperature sensitive and Ca2+ permeable TRPV3 channels expressed in the ORS cells by natural skin sensitizer carvacrol increased the apoptosis of human ORS cells. Silencing of TRPV3 by short-hairpin RNA reversed the cell... view more»

Abstract