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Knox D Author
Subjects of specialization
Affiliation
HIV, HIV drug resistance, HIV prevention
Maple Leaf Medical Clinic, Canada
Biography
Dr. David Knox is an HIV Primary Care physician in Toronto, Canada at Maple Leaf Medical Clinic. In 2005 he received the Academic Gold Medal in Honors Bachelor Medical Sciences from the University of Western Ontario. He received his Doctor of Medicine from the University of British Columbia in 2011 and completed a Family Medicine residency at the University of Toronto in 2013. He is an accredited HIV SpecialistTM with the American Academy of HIV Medicine
Publications
Research Article Open Access
Impact of Baseline NNRTI Resistance in Antiretroviral-naïve Patients with HIV in A Large Urban Clinic
Author(s): Steinberg S, Loutfy M, Sandler I, Varriano B, Smith G, Kovacs C, Brunetta J, Chang B, Merkley B, Tilley D, Fletcher D, Acsai M, Knox D and Crouzat F
Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are prone to baseline resistance and potential early treatment failure. We investigated the NNRTI resistance profiles of antiretroviral therapy (ART)–naive patients with HIV in a large urban clinic and assessed their response to initial ART.
Materials and Methods: This was a retrospective cohort study of ART-naive patients, who had baseline genotypes, starting ART prior to July 16, 2015. Cox regression was used to determine the impact on time to viral suppression with baseline NNRTI resistance as the primary covariate of interest. Of those who achieved virologic suppression, Cox regression was used to determine the impact on viral rebound [viral load (VL) ≥ 200 copies/... view more»
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