Kwabena J Sarfo Author

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Immuno-detection of PPAR overexpression with no change protein turnover endocardial tissues suggests major alterations in energy metabolism during ischemic and dilated cardiomyopathy conditions of heart

Author(s):

Kwabena J Sarfo and Theresia Thalhammer

Immuno-Detection of PPAR Overexpression in Protein Turnover in Endocardial Tissues Suggesting Alterations in Energy Metabolism during Ischemic and Dilated Cardiomyopathy Conditions

The peroxisome proliferator-activated receptor (PPAR) family regulates genes encoding enzymes involved in fatty acid and glucose metabolism. This role in the high-energy consuming heart organ has been a major target in cardiomyopathy studies. PPARs and nuclear protein levels were investigated in endocardial tissues samples obtained from ischemic and dilated cardiomyopathy male patients. Control samples were obtained from male accident victims of same age group. The expression of PPAR isoforms in each sample was analyzed... view more»

DOI: 10.4172/2324-8602.1000229

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