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Loutfy M Author
Subjects of specialization
Affiliation
Infectious Diseases, HIV, STD
Maple Leaf Medical Clinic, Canada Department of Medicine, University of Toronto, Canada Women
Biography
Dr. Mona Loutfy is an Infectious Diseases Specialist, Clinician Scientist and Full Professor at the University of Toronto and Women’s College Hospital in Toronto. Her main clinical practice is at the Maple Leaf Medical Clinic where she specializes in care of women, youth and couples with HIV and reproductive health and HIV. She founded the Women and HIV Research Program at the Women’s College Research Institute
Publications
Research Article Open Access
Impact of Baseline NNRTI Resistance in Antiretroviral-naïve Patients with HIV in A Large Urban Clinic
Author(s): Steinberg S, Loutfy M, Sandler I, Varriano B, Smith G, Kovacs C, Brunetta J, Chang B, Merkley B, Tilley D, Fletcher D, Acsai M, Knox D and Crouzat F
Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are prone to baseline resistance and potential early treatment failure. We investigated the NNRTI resistance profiles of antiretroviral therapy (ART)–naive patients with HIV in a large urban clinic and assessed their response to initial ART.
Materials and Methods: This was a retrospective cohort study of ART-naive patients, who had baseline genotypes, starting ART prior to July 16, 2015. Cox regression was used to determine the impact on time to viral suppression with baseline NNRTI resistance as the primary covariate of interest. Of those who achieved virologic suppression, Cox regression was used to determine the impact on viral rebound [viral load (VL) ≥ 200 copies/... view more»
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