Medet Jumabay Author

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Dedifferentiated Adipocytes Improve Heart Function Post-Myocardial Infarction

Author(s):

Eric J Tsang, Maria C Jordan, Kenneth P Roos, Jessica M Gluck, Medet Jumabay, Kristina I Boström, Richard J Shemin and Sepideh Heydarkhan-Hagvall

Background:The development of pluripotent stem cell-based strategies for regenerative medicine offers hope of one day having a limitless source of therapeutic cells for the repairing of damaged cardiac tissue resulting from myocardial infarction (MI). Dedifferentiated adipose cells (DFAT) have recently gained attention in this regard for their in vitro and in vivo ability to express vascular and cardiac-specific markers. To date, there is limited knowledge with respect to their capacity to improve cardiac function and contractility when introduced into the myocardium after the onset of MI. To that end, this study investigated the in vivo potential of intramyocardially injected mouse DFAT (mDFAT) cells to differentiate towards cardiovascular lineages and enhance cardiac ... view more»

DOI: 10.4172/2325-9620.1000135

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