Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Journal of Aging and Geriatric MedicineISSN: 2576-3946
Melnyk NO Author
Subjects of specialization
Affiliation
Age; cuprizone; LIF; Neuron; Behavioral reactions; Macrophages; Antioxidant enzymes
Cell and Tissue Technologies Department, State Institute of Genetic and Regenerative Medicine, NAMS of Ukraine, Keiv, Ukraine
Biography
| Melnyk NO Cell and Tissue Technologies Department, State Institute of Genetic and Regenerative Medicine, NAMS of Ukraine, Keiv, Ukraine |
Publications
Research Article Open Access
Cuprizone-Induced Disorders of Central Nervous System Neurons, Behavioral Reactions, Brain Activity of Macrophages and Antioxidant Enzymes in the Mice of Different Ages: Role Leukemia Inhibitory Factor in Their Improvement
Author(s): Labunets IF, Melnyk NO, Rodnichenko AE, Rymar SE and Utko NA
Objective: The present work aimed at studying neuroprotective effects of recombinant human leukemia inhibitory factor (rhLIF) on mice of different ages with cuprizone model of demyelination.
Methods:In the 129/Sv mice at 3-5 and 16-17 months of age we assessed (a) motor and emotional activity in the “open field” test and (b) activity of brain antioxidant enzymes and macrophages capable to phagocytosis of latex beads. After staining histological sections of the brain and spinal cord toluidin blue we determined the percentage of neurons with unmodified, moderate and severe structural changes. Cuprizone was fed daily for 3 weeks. RhLIF was inject... view more»
Google Scholars / Researchers Sites
