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Merkley B Author
Subjects of specialization
Affiliation
HIV/AIDS
Maple Leaf Medical Clinic, Canada
Biography
Dr. Barry Merkley graduated University of Toronto medical school in 1990 following an undergraduate degree in microbiology and molecular genetics. He completed a residency in family medicine at Wellesley Hospital. Since 1992 he has practiced family medicine with a focus on HIV primary care in central Toronto. He has served on the Ontario Advisory Committee on HIV/AIDS and is active in clinical research. He joined the Maple Leaf Medical team in September 2005.
Publications
Research Article Open Access
Impact of Baseline NNRTI Resistance in Antiretroviral-naïve Patients with HIV in A Large Urban Clinic
Author(s): Steinberg S, Loutfy M, Sandler I, Varriano B, Smith G, Kovacs C, Brunetta J, Chang B, Merkley B, Tilley D, Fletcher D, Acsai M, Knox D and Crouzat F
Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are prone to baseline resistance and potential early treatment failure. We investigated the NNRTI resistance profiles of antiretroviral therapy (ART)–naive patients with HIV in a large urban clinic and assessed their response to initial ART.
Materials and Methods: This was a retrospective cohort study of ART-naive patients, who had baseline genotypes, starting ART prior to July 16, 2015. Cox regression was used to determine the impact on time to viral suppression with baseline NNRTI resistance as the primary covariate of interest. Of those who achieved virologic suppression, Cox regression was used to determine the impact on viral rebound [viral load (VL) ≥ 200 copies/... view more»
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