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Hindi VEGETOS: An International Journal of Plant ResearchOnline ISSN: 2229-4473
Print ISSN: 0970-4078
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Mi-Rae Shin Author
Publications
Research Article Subscription
Anticonvulsant Effect of Gastrodia Rhizome Processed at Different Steaming Times with Scavenging NO and Antiinflammatory Activity
Author(s): Mi-Rae Shin, Bu-Il Seo, Kwon OJ and Seong-Soo Roh
Purpose: To evaluate Anticonvulsant effect of Gastrodia Rhizome processed at different steaming times in Pilocarpine, Pentylenetetrazol (PTZ), and Strychnine induced mice seizure model. Methods: Gastrodia rhizome extracts divided with or without steaming process. Gastrodin content of all extracts was evaluated to use by High-Performance Liquid Chromatography (HPLC). In vitro, Gastrodia rhizome extracts were evaluated for its antiimflammatory activity by NO, DPPH and ABST assay in RAW 264.7 cells. Furthermore, we examined anticonvulsant activites in Pilocarpine, PTZ, and Strychnine induced seizure animal model. Results: The more increase of steaming time with GR, resulted the more contents of gastrodin, total phenol and flavonoid, more effec... view more»