Mohamed Gamal Shiha Author

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Oval Cells in Response to Partial Hepatectomy and Bile Duct Ligation: Flow Cytometric Analysis

Author(s):

Hussein Abdellatif, Mohamed Gamal Shiha

Background: The liver has an impressive capacity for regeneration, However, in cases of severe injury, bipotent progenitors (oval cells) are activated. Such cells are capable of differentiation into hepatocytes and cholangiocytes.

Aim: To detect change in oval cells population in response to partial hepatectomy (PH) and bile duct ligation (BDL) and using a flow cytometric based method.

Methods: 24 female albino rats randomly divided into three groups (A) control, (B) Partial hepatectomy (PH) (C) Bile duct ligation (BDL) group. Animals sacrificed 9 days post injury. Biochemical analysis was performed. Percentage of oval cells in liver t... view more»

DOI: 10.4172/2325-9620.1000131

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