Mohammad Mir Author

Annual Meeting Abstract Open Access

Euro Virology 2019 STD-HIV AIDS 2019: Hantavirus RdRp requires a host cell factor for Cap Snatching - Mohammad Mir - Western University of Health Sciences

Author(s):

Mohammad Mir

The hantavirus RNA -dependent ribonucleic acid catalyst (RdRp) snatches 5' capped RNA fragments from the host cellular transcripts and makes use of them as primers to impress transcription and replication of the viral genome inside the cytoplasm of infected cells. Hantavirus nucleocapsid protein (N protein) binds to the 5' caps of host cellular mRNA and protects them from the attack of cellular decapping machinery. N protein rescues lengthy capped mRNA fragments in cellular P our bodies which can be later processed via an unknown mechanism to generate 10- to 14-nucleotide-lengthy capped RNA primers with a 3' G residue. Hantavirus RdRp has an N-terminal endonuclease area and a C-terminal uncharacterized domain that harbors a binding web page for the N protein. The sublimate n... view more»

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