Mshelia HE Author

Research Article Open Access

Comparative Study of Antiplasdodial Activity of Aqueous Leaves Extract of Azadirachta indica (Juss), Senna occidentalis (Linn) and Standard Antimalaria on Multiplication of Plasmodium falciparum (Laveran)

Author(s):

Alkali K, Abdullahi K, Mshelia HE, Yahaya MA, Abubakar N and Tarbutu AG

Malaria is a major public health problem in the world, but treatment of malaria is becoming more difficult due to increasing drug resistance and high cost of antimalaria. This study investigated the antiplasmodial effects of leaves extract of Azadirachta indica, Senna occidentalis and standard antimalaria using RPMI 1640 culture media (in vitro). Parasite density was determined by counting the number of Plasmodium falciparum infected erythrocyte in 5,000 erythrocytes of the culture, thin blood smear were prepared and stained with Giemsa stain. Varying concentrations of the extracts such as 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100 mg/mL were prepared, the effect of the leaves extracts against the growth of schizonts were dose dependant. A.indica showed high... view more»

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