Mutsuga M Author

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Stem Cell Therapy for Aortic Aneurysm: Does the Administered Cell Type Influence the Therapeutic Effects?

Author(s):

Yamawaki-Ogata A, Fujimoto KL, Mutsuga M, Tokuda Y, Usui A; Narita Y

Objective: We previously demonstrated that Mesenchymal Stem Cells (MSCs) represent a novel alternative therapeutic tool for treatment of aortic aneurysm (AA). MSCs can be obtained from Bone Marrow (BM) and Adipose Tissue (AD), but the cells from these two sources have different characteristics. In this study, we examined BM-MSCs, AD-MSCs, and Dermal Fibroblast (D-FBs) in order to determine the appropriate sources of cells for treatment of AA. Methods: We compared cell proliferation, population doubling time (PDT), cell surface markers, and trophic proteins among the three cell types. We then evaluated AA diameter, medial elastin area, existence rate of AA, and MMP-2 and -9 activities following intravenous injection of each type of cells into angiotensin IIin... view more»

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