International Journal of Mental Health & PsychiatryISSN: 2471-4372

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Nigel Gericke Author

gerickenigel@gmail.com

Subjects of specialization
cAMP; Phosphodiestease; Serotonin; Zembrin extract; Sceletium tortuosum; Alzheimer?s disease

Affiliation
Director, Medical and Scientific, HG & H Pharmaceuticals (Pty) Ltd., Bryanston, South Africa

Biography

South African doctor and medical ethnobotanist. Nigel Gericke was born in Johannesburg and studied botany and later medicine at Witwatersrand University. In 1977, with fellow students C.P. Peeters and G.G. Burelli, he undertook a survey of Bophuthatswana. He has practised in the public health sector in rural, township, and academic settings in South Africa, and also as a district medical officer in Labrador, Canada. Now based in Cape Town, he is an independent scientific and medical consultant in the area of medicinal plant innovation and product development. In 1998, together with like-minded colleagues

Publications

Review Article Subscription

Exploring Zembrin Extract Derived from South African Plant, Sceletium tortuosum in Targeting cAMP-driven Phosphodiesterase (PDE) Signaling in Alzheimer’s Disease: Synthesis of Evidence

Author(s):

Simon Chiu, Hana Raheb, Kristen Terpstra, JoshVaughan, Michel Farina-Woodbury, Yves Bureau, Zack Cernovsky, Jirui Hou, John Copen, Mariwan Husni, Vladimir Badmeav, Ana Hategan, Mujeeb Shad, Zach Suntras, Nigel Gericke

Recently with the changing landscape of the aging population and the increase in incidence of Alzheimer’s disease (AD), there has been marked interest to develop strategies to prevent, delay and modify AD. We review the diverse lines of evidence in support of the emerging role of cAMP-mediated Phosphodiesterase (PDE) signalling with respect to aging, inflammation and depression. In view of the link of PDE to Epigenetic complex, targeting PDE through designing modulators and inhibitors of PDE may represent a novel approach in AD therapeutics. We... view more»

DOI: 10.4172/2471-4372.1000104

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