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Hindi Journal of Chemistry and Applied Chemical EngineeringISSN : 2576-3954
Nira Ben Jonathan Author
Subjects of specialization
Affiliation
Chemistry, Thermo Dynamics, Thermal decomposition, Mechanistic aspects, Combustion
University of Cincinnati Medical Center: Cincinnati, OH, US.
Biography
Nira Ben Jonathan; University of Cincinnati Medical Center: Cincinnati, OH, US. He stated that, "Using tissue microarrays, D1R was overexpressed in 30% of 751 primary breast carcinomas, and was undetectable in normal breast tissue. D1R overexpression was associated with larger tumors, higher grades, node metastasis, and shorter patient survival."
Publications
Short Communication Open Access
Dopamine receptor Type 1 (D1R) in breast cancer: Expression, signaling, and therapeutic applications
Author(s): Nira Ben Jonathan
Dopamine (DA) is a catecholamine which acts as a neurotransmitter in the brain and as a circulating hormone in the periphery. DA binds to five G-protein-coupled receptors, classified by their ability to increase cAMP (D1R and D2R) or decrease cAMP (D2R, D3R and D4R). We discovered D1R overexpression in breast cancer cell lines and tumors, thus identifying this receptor as a biomarker and a novel therapeutic target in breast cancer. Using tissue microarrays, D1R was overexpressed in 30% of 751 primary breast carcinomas, and was undetectable in normal breast tissue. D1R overexpression was associated with larger tumors, higher grades, node metastasis, and shorter patient survival. Unexpectedly, selective D1R agonists signal via the cGMP/protein kinase G (PKG) pathway. Activators of this pa... view more»
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