Noriko Matsushita Author

Research Article Subscription

Targeted MicroRNA Interference Promotes Postnatal Cardiac Cell Cycle Re-Entry

Author(s):

Yiqiang Zhang, Noriko Matsushita, Tamar Eigler and Eduardo Marban

Targeted MicroRNA Interference Promotes Postnatal Cardiac Cell Cycle Re-Entry

Mammalian heart cells undergo a marked reduction in proliferative activity shortly after birth, and thereafter grow predominantly by hypertrophy. Our understanding of the molecular mechanisms underlying cardiac maturation and senescence is based largely on studies at the whole-heart level. Here, we investigate the molecular basis of the acquired quiescence of purified neonatal and adult cardiomyocytes, and use microRNA interference as a novel strategy to promote cardiomyocyte cell cycle re-entry. Expression of cyclins and cyclin-dependent kinases (CDKs) and positive ... view more»

DOI: 10.4172/2325-9620.1000108

Abstract HTML PDF