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Hindi Journal of Blood Research & Hematologic Diseases
Richard J Drsquo;Andrea Author
Subjects of specialization
Affiliation
Wnt/?-Catenin, Leukemic stem cell, Self-renewal , Hematopoietic stem cell, Drug-Resistance
Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia.
Biography
Richard J Drsquo is a professor emeritus in pediatrics of the “G. Gaslini” scientific children’s hospital of Geneva. He is expert reviewer for European commission framework programmer 7th research proposals in bioethics and life sciences, Brussels, are. Luisa M Massimo is an expert for new Eurasia foundation.
Publications
Review Article Open Access
The Role of Wnt/β -Catenin Signaling in Normal and Malignant Hematopoiesis, Hemostasis
Author(s): Teresa Sadras, Richard J D’Andrea and Deborah L White
The Wnt/β-catenin signaling plays indispensable roles in embryonic development and adult homeostasis. Through diverse mechanisms which are partially defined, abnormal activation of β-catenin occurs frequently in neoplastic disease. A critical function for Wnt/β-catenin in solid tumors, in particular colorectal cancer, has been well characterized. Increasing evidence indicates that this pathway is also deregulated in hematological malignancies. In acute myeloid leukemia, enhanced β-catenin levels are observed in a large proportion of patients, and correlates with... view more»
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