Richard J Shemin Author
Subjects of specialization
Affiliation
Thoracic Surgery, Adult Cardiac Surgery, Aortic Surgery, Cardiovascular Surgery
Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, USA
Dr. Shemin is currently serving as the President of the American Heart Association, Greater Boston Division and President of the Massachusetts Chapter of the Society of Thoracic Surgeons and is the immediate past President of the Northeast Cardiac Surgery Society.He is an Associate Editor for Circulation, and the Journal of Cardiac Surgery.
Research Article Subscription
Author(s): Eric J Tsang, Maria C Jordan, Kenneth P Roos, Jessica M Gluck, Medet Jumabay, Kristina I Boström, Richard J Shemin and Sepideh Heydarkhan-Hagvall
Background:The development of pluripotent stem cell-based strategies for regenerative medicine offers hope of one day having a limitless source of therapeutic cells for the repairing of damaged cardiac tissue resulting from myocardial infarction (MI). Dedifferentiated adipose cells (DFAT) have recently gained attention in this regard for their in vitro and in vivo ability to express vascular and cardiac-specific markers. To date, there is limited knowledge with respect to their capacity to improve cardiac function and contractility when introduced into the myocardium after the onset of MI. To that end, this study investigated the in vivo potential of intramyocardially injected mouse DFAT (mDFAT) cells to differentiate towards cardiovascular lineages and enhance cardiac ... view moreĀ»