Sai Prasad Author

Research Article Open Access

Using Na3PO4 to Enhance In vitro Animal Models of Aortic Valve Calcification

Author(s):

Daniel Alejandro Lerman, Sai Prasad and Nasri Alotti

Using Na₃PO₄ to Enhance In vitro Animal Models of Aortic Valve Calcification

Background/Objectives: The pathogenesis of calcific aortic valvular disease (CAVD) involves an active inflammatory process of valvular interstitial cells (VICs) characterized by the activation of specific osteogenic signaling pathways and apoptosis. This process can be studied by analyzing certain molecular markers and gene expression pathways of spontaneous calcification. The purpose of our study is to investigate the role of sodium phosphate (Na₃PO₄) as a calcification promoter, with the... view more»

DOI: 10.4172/2324-8602.1000250

Abstract HTML PDF