Shaimaa Ahmed Abdel-Mougood Author

Short Communication Open Access

Expression of antiapoptotic survivin gene in treated and untreated Ehrlich tumor bearing mice with prodigiosin as a significant marker

Author(s):

Shaimaa Ahmed Abdel-Mougood

Introduction & Aim: Survivin gene is a member of IAP (Inhibitors of Apoptosis Proteins) family. It’s over expression has been demonstrated in tumors of breast, as well as in esophagus, pancreas, bladder, uterus, cervix, ovary, large-cell non-Hodgkin’s lymphoma and leukemia, neuroblastomas, melanomas, gastric tumors, colon, stomach, liver, oral, thyroid, laryngeal, osteosarcoma and prostate cancer. The main objective was to investigate the level of this marker in treated and untreated Ehrlich tumor bearing mice with prodigiosin (a red pigment extracted from Serratia marcesens has different biological functions) and study of its relationship with the growth of tumor and survival of Ehrlich tumor bearing mice. Methods: Apoptosis was investigated by immunohistochemistry stai... view more»

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