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Steinberg S Author
Subjects of specialization
Affiliation
Antiretroviral therapy, HIV
Maple Leaf Medical Clinic, Canada University of Guelph, Canada
Biography
Dr. Steinberg obtained his PhD in 2002 from the University of Guelph. His research thesis was conducted in the laboratory of Professor David Dyck where he studied the regulation of metabolism in muscle by the hormone leptin. From 2002-2006, Dr. Steinberg conducted Postdoctoral Research in the laboratory of Professor Bruce Kemp at St. Vincent’s Institute of Medical Research in Melbourne, Australia.
Publications
Research Article Open Access
Impact of Baseline NNRTI Resistance in Antiretroviral-naïve Patients with HIV in A Large Urban Clinic
Author(s): Steinberg S, Loutfy M, Sandler I, Varriano B, Smith G, Kovacs C, Brunetta J, Chang B, Merkley B, Tilley D, Fletcher D, Acsai M, Knox D and Crouzat F
Background: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are prone to baseline resistance and potential early treatment failure. We investigated the NNRTI resistance profiles of antiretroviral therapy (ART)–naive patients with HIV in a large urban clinic and assessed their response to initial ART.
Materials and Methods: This was a retrospective cohort study of ART-naive patients, who had baseline genotypes, starting ART prior to July 16, 2015. Cox regression was used to determine the impact on time to viral suppression with baseline NNRTI resistance as the primary covariate of interest. Of those who achieved virologic suppression, Cox regression was used to determine the impact on viral rebound [viral load (VL) ≥ 200 copies/... view more»
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