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Hindi VEGETOS: An International Journal of Plant ResearchOnline ISSN: 2229-4473
Print ISSN: 0970-4078
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Stephen Adeniyi Adefegha Author
Publications
Research Article Subscription
Inhibitory Activities of Brimstone (Morinda lucida) Roots Extract on α-Amylase and α-Glucosidase – In vitro
Author(s): Stephen Adeniyi Adefegha and Olorunfemi Raphael Molehin
Brimstone (Morinda lucida) root is one of the widely used herbs in folkore medicine for the management of diabetes while acarbose is a well-known antidiabetic drug. This study sought to characterize the phenolic constituents of brimstone (Morinda lucida) root, assess its interaction with key enzymes (α-amylase and α-glucosidase) relevant to type-II diabetes and evaluate its effect on acarbose in vitro. One milligram per millilitre of aqueous extract of brimstone root and acarbose were separately prepared. In addition, both the brimstone and acarbose solution (50:50 v/v) were thoroughly mixed until homogeneity was attained. The phenolic phytoconstituents of brimstone root were subsequently determined. Finally, the effects of brimstone root extract, acarbose solution and a mix... view more»