Taku Kato Author

Research Article Open Access

Short-Term Treatment with an Angiotensin II Receptor Blocker Prevents Necrotic Core Formation by Inhibiting Oxidative Stress-Mediated Apoptosis in Macrophages

Author(s):

Sou Kishida, Hiroyuki Yamada, Noriyuki Wakana, Hiroyuki Kawahito, Daisuke Irie, Taku Kato, Masakazu Kikai, Kensuke Terada, Keita Yamamoto, Naotoshi Wada, Shinichiro Motoyama, Hiroki Takata, Hirokazu Yokoi, Yoshinori Tsubakimoto, Takehiro Ogata, Tomomi Ueyama and Satoaki Matoba

Short-Term Treatment with an Angiotensin II Receptor Blocker Prevents Necrotic Core Formation by Inhibiting Oxidative Stress-Mediated Apoptosis in Macrophages

Objective: To study the role of angiotensin II (Ang II) type 1 receptor (AT1R) on necrotic core formation associated with endoplasmic reticulum (ER) stress-induced macrophage apoptosis.

Methods and Results: Eight-week-old ApoE-deficient mice were fed a high-cholesterol diet and administered AT1R blocker (ARB), hydra... view more»

DOI: 10.4172/2324-8602.1000252

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