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Hindi Journal of Regenerative MedicineISSN: 2325-9620
Tamar Eigler Author
Subjects of specialization
Affiliation
Cardiology, Medicine, Cardiomyocytes
Cedars-Sinai Heart Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Biography
Tamar Eigler is working at Cardiology in Cedars-Sinai Heart Institute,8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Her Reserach interst are Cardiology, Medicine, Cardiomyocytes.Tamar Eigler Weizmann Institute of Science weizmann · Department of Biological Regulation PhD.
Publications
Research Article Subscription
Targeted MicroRNA Interference Promotes Postnatal Cardiac Cell Cycle Re-Entry
Author(s): Yiqiang Zhang, Noriko Matsushita, Tamar Eigler and Eduardo Marban
Targeted MicroRNA Interference Promotes Postnatal Cardiac Cell Cycle Re-Entry
Mammalian heart cells undergo a marked reduction in proliferative activity shortly after birth, and thereafter grow predominantly by hypertrophy. Our understanding of the molecular mechanisms underlying cardiac maturation and senescence is based largely on studies at the whole-heart level. Here, we investigate the molecular basis of the acquired quiescence of purified neonatal and adult cardiomyocytes, and use microRNA interference as a novel strategy to promote cardiomyocyte cell cycle re-entry. Expression of cyclins and cyclin-dependent kinases (CDKs) and positive ... view more»
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