Tamer Mosaad Ragaband Radwa AbdulHarris AboZeid Author

Review Article Open Access

Serum Neuron Specific Enolase use in Detecting Brain Injury in Children with Congenital Heart Disease before Undergoing Cardiac Surgery

Author(s):

Heba Ahmed ElAwady , Hadeer Mahmoud AbdelGhaffar , Mohamed Mansour Abbas Eid , Tamer Mosaad Ragab and Radwa AbdulHarris AboZeid

Background: Many children with Congenital Heart Disease (CHD) suffer from neurological derangements, whether clinically evident or subtle. Brain injury may be pre-existing before surgery, making them at increased risk of adverse perioperative neurological outcomes. Serum Neuron-Specific Enolase (sNSE) is a well appreciated marker for neuronal damage that has been demonstrated to detect perioperative brain affection in children with CHD. Aim of the study: The study aimed to utilize sNSE to detect presence of brain injury in children with CHD prior to performing cardiac surgery. Methods: The study included 85 children divided into two groups; Group I included 45 patients with CHD while Group II (control) included 40 healthy children of the same age group. Patients were included if they ha... view more»

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