Tariq M Rana Author

Annual Meeting Abstract Open Access

Euro Virology & STD-HIV AIDS 2019: Targeting Vif regulatory Axis: developing new AIDS therapies - Tariq M Rana - University of California San Diego

Author(s):

Tariq M Rana

The human host is invaded via a wide variety of microbial pathogens and has evolved a number of protecting mechanisms to continue to exist these infections. In addition to adaptive immunity, it is miles becoming increasingly clearer that innate immunity performs a critical function in defensive host organisms from infections. One of the innate immune response mechanisms against viral infections includes a protein circle of relatives, APOBEC3 (apolipoprotein B mRNA modifying enzyme catalytic polypeptide 3). The APOBEC3 family of proteins can restrict replication of exogeneous retroviruses in addition to Hepatitis B, a DNA virus that replicates thru an RNA intermediate, and inhibit replication of retrotransposons. APOBEC3G (A3G) protein famous the most powerful block to HIV-1 replication.... view more»

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