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Hindi Journal of Blood Research & Hematologic Diseases
Teresa Sadras Author
Subjects of specialization
Affiliation
Wnt/?-Catenin; , Hematopoietic stem cell, Leukemic stem cell, Self-renewal, Drug-Resistance
Cancer Theme, South Australian Health & Medical Research Institute, Adelaide, SA, Australia
Biography
Dr. Sadras received her PhD from the University of Adelaide and Centre for Cancer Biology in Australia and worked as a postdoctoral researcher at the South Australian Health and Medical Research Institute before joining the Beckman Research Institute at the City of Hope, also as a postdoctoral researcher.
Publications
Review Article Open Access
The Role of Wnt/β -Catenin Signaling in Normal and Malignant Hematopoiesis, Hemostasis
Author(s): Teresa Sadras, Richard J D’Andrea and Deborah L White
The Wnt/β-catenin signaling plays indispensable roles in embryonic development and adult homeostasis. Through diverse mechanisms which are partially defined, abnormal activation of β-catenin occurs frequently in neoplastic disease. A critical function for Wnt/β-catenin in solid tumors, in particular colorectal cancer, has been well characterized. Increasing evidence indicates that this pathway is also deregulated in hematological malignancies. In acute myeloid leukemia, enhanced β-catenin levels are observed in a large proportion of patients, and correlates with... view more»
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