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Hindi Journal of Blood Research & Hematologic Diseases
Terufumi Yamaguchi Author
Subjects of specialization
Affiliation
HTLV-I, Retinoid, Senescence, ROS, Redox
Department of Hematology, National Hospital Organization Osaka Minami Medical Center, Osaka, Japan
Biography
Terufumi Yamaguchi is a researcher for blood and hematologic diseases. Published more number of articles which is usefull for blood cancer. Uchiyama T, Yodoi J, Sagawa K, Maeda Y, Yamaguchi T, Hijikata Y, Tanaka M, Hirase C, et al. (2008)Clinical efficacy of all-trans retinoic acid for treating adult T-cell leukemia. J Cancer Res ClinOncol134: 673-677.Takatsuki K, Uchino H (1977) Adult T cell leukemia: Clinical and hematological features of 16 cases. Blood 50: 481-492.,
Publications
Short Communication Open Access
Relationship between Cellular Senescence and Redox Potential on Adult T-Cell Leukemia Cells
Author(s): Yasuhiro Maeda, Atsushi Okamoto, Shin-ichiro Kawaguchi, Akiko Konishi, Kenta Yamamoto, Go Eguchi and Terufumi Yamaguchi
Human T-cell leukemia virus type I (HTLV-I) is a human retrovirus and an etiologic agent of adult T-cell leukemia/lymphoma (ATL/ ATLL). The subtypes acute and lymphoma have a poor prognosis with median survival rate of approximately 6 months. Some excellent therapeutic strategies for ATL are required. Retinoids [all-trans retinoic acid (ATRA) and tamibarotene (Am-80) have been reported to inhibit the in vitro growth of HTLV-1 [+] T-cell lines and that of fresh cells obtained from patients with adult T-cell leukemia (ATL). We showed a clinical efficacy of retinoid therapy in tr... view more»
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